Will both models of the Nest Thermostat work with this system?

Thank you for your question. Yes, the Nest thermostat will work with any commercial 24v thermostat. When connecting this thermostat, please follow the guidelines in the QuickStart thermostat wiring guide, which is located under resources in the product specifications section of the product page. Be sure to change the O/B setting to energize for heat. By default the heat pump setting in the Nest energizes on cooling. For more assistance, please give us a call.